A 25-year-old motorcycle rider and his 17-year-old passenger have suffered serious injuries during a collision on the A27 in Salvington on Friday night (Nov 18).
It happened at around 9.25pm on Crockhurst Hill and police are hoping witnesses or anyone with footage will come forward.
A 25-year-old man, who was driving the motorcycle suffered serious injuries. A 17-year-old girl, who was a passenger, sustained life-threatening injuries and remains in a critical condition in hospital.
Her next of kin are being supported by specially trained officers.
Officers are eager for anyone with information, dashcam, or video doorbell footage at the time of the collision or may have witnessed a motorcyclist with a pillion passenger around that area to come forward.
A report can be made to Sussex Police online, or by calling 101, quoting Operation Loxton.